One natural compound.
What It Is
Hypoestoxide (HE) is an active pharmaceutical ingredient (API), isolated and purified from an herbal plant, Hypoestes rosea, from indigenous Nigerian flora. It has anti-malarial, anti-inflammatory, anti-cancer, anti-viral, anti-Parkinson's disease, and anti-Leishmaniasis activities, respectively.
Due to its complex chemical structure, Hypoestoxide cannot be synthesized in the laboratory. Hypoestoxide is abundant in the leaves of the parent plant, Hypoestes rosea (0.1% by dry weight of leaves).
This is no doubt a robust natural synthetic process, considering that Taxol, a common anti-cancer chemotherapy drug and a related natural diterpene, is 0.01% of the yew tree bark which needs up to 20 years for full growth. H. rosea is a hardy shrub which reproducibly provides the natural product of interest, Hypoestoxide.
Hypoestoxide (HE) is a diterpene which features a bicyclo [9,3,1] pentadecane ring system and contains two epoxide moieties, an alpha beta-unsaturated ketone, an acetylated alcohol group, and seven stereo centers.
Compounds containing epoxides and alpha beta-unsaturated ketones are often associated with alkylator properties and are therefore, usually toxic. HE however, is non-toxic—based on results from several in-house and independent studies.