One natural compound.
Multiple indications.


What It Is

Hypoestoxide (HE) is an active pharmaceutical ingredient (API), isolated and purified from an herbal plant, Hypoestes rosea, from indigenous Nigerian flora. It has anti-malarial, anti-inflammatory, anti-cancer, anti-viral, anti-Parkinson's disease, and anti-Leishmaniasis activities, respectively. 


Its Uniqueness

Due to its complex chemical structure, Hypoestoxide cannot be synthesized in the laboratory. Hypoestoxide is abundant in the leaves of the parent plant, Hypoestes rosea  (0.1% by dry weight of leaves). 

This is no doubt a robust natural synthetic process, considering that Taxol, a common anti-cancer chemotherapy drug and a related natural diterpene, is 0.01% of the yew tree bark which needs up to 20 years for full growth. H. rosea is a hardy shrub which reproducibly provides the natural product of interest, Hypoestoxide. 


Its Chemistry

Hypoestoxide (HE) is a diterpene which features a bicyclo [9,3,1] pentadecane ring system and contains two epoxide moieties, an alpha beta-unsaturated ketone, an acetylated alcohol group, and seven stereo centers.

Compounds containing epoxides and alpha beta-unsaturated ketones are often associated with alkylator properties and are therefore, usually toxic. HE however, is non-toxic—based on results from several in-house and independent studies.